TriMix Penile Injections

TriMix Penile Injections


Trimix is a mixture of Papaverine, Phentolamine and Alprostadil (PGE).

  • Papaverine: PDE5 Inhibitor Similar to Viagra & Cialis, but more direct
  • Phentolamine: Alpha Adrenergic Blocker, preventing blood from leaving the penis
  • Alprostadil: Increases cellular cAMP, causing smooth muscle relaxation & vasodilation

Each of these drugs produce a vasodilating effect when injected into the penis. The injection is done using a very small needle, inserted into the proper area along the shaft of the penis. Trimix injection therapy is recognized as a viable treatment for erectile dysfunction by the American Urological Society.

Trimix is an effective 2nd line therapy for patients who have trouble experiencing erections after trying PDE5 inhibitors like (Viagra®, Levitra®, Cialis®).

schedule an appointment


Trimix injections can provide longer and fuller erections with the potential of lasting through climax, allowing you to maintain and improve your sexual health. An intracavernous injection is the most effective non-surgical treatment for ED, according to the American Urologic Association. Penile injections, unlike most oral medications, can produce an erection in less than 5 minutes.



You will have your first TriMix Injection in our medical office under the supervision of a Hormone Zone physician. You will be instructed on the proper technique of how to inject yourself. The needle is very small, the technique is easy to learn, and the injection is very simple and painless. After the injection, you will have time to comfortably and privately wait in the exam room to achieve an erection. This will take approximately 10 to 20 minutes. The goal for the first TriMix Injection will be to achieve an erection that is firm enough for sexual penetration. We use a scale of 0 to 10, with zero out of 10 being no reaction at all, a 6 out of 10 being just firm enough for sexual penetration, and up to 10 out of 10 being the most favorable erection results.


Depending on your in office results, your Hormone Zone physician will provide you with three (3) different doses of TriMix Injections of varying strengths to take home to continue to experiment. For example, you may have been given three (3) injections at the dose of 8, 10, and 12 units. Each day, you will inject one (1) of your TriMix Injections at a time and determine your results. Never inject the TriMix more than once in a 24 hour period, regardless of results.

Once you have determined your optimal dose at home, you will simply contact the office and let us know your optimal dose. Since the TriMix Injection Package was based on ten (10) injections, you will be supplied with an additional six (6) TriMix injections.

In the future, additional TriMix Injection Packages will be set at your optimal dose and you will receive all of them at once.