TriMix Penile Injections

TriMix Penile Injections for Erectile Dysfunction

Every year, between 15 and 30 million men suffer from some form of erectile dysfunction, but despite its prevalence, there is no one-size-fits-all solution for treating it. Many men will see great results from one treatment while many more will experience no improvement at all, so it’s important for there to be an array of alternatives if something isn’t working.

At The Hormone Zone, we know there is no silver bullet to treating ED; restoring and improving your erectile function takes a tailored and deliberate approach that addresses the variety of factors that could be contributing to your condition. That’s why we are proud to offer TriMix penile injections as part of our comprehensive approach to ED treatment designed to help you feel and function your best in the bedroom.

TriMix penile injections can be effective for patients with little to no success using traditional PDE5 inhibitors like Viagra®, Levitra®, or Cialis® on their own. By combining three proven ED medications into one compounded injectable, TriMix injections provide a safe, easy, and non-surgical option for men with ED to achieve and sustain longer, fuller erections firm enough for sex.

What is TriMix?

TriMix is a specially compounded injectable medication that takes the proven ED therapy of the vasodilator alprostadil, a chemically-identical form of prostaglandin E1 (PGE1) and potent vasodilator which enhances its performance with two other ED drugs, papaverine and phentolamine. These three drugs work synergistically to relax the muscles and widen the blood vessels in the penis—allowing for the blood flow necessary to achieve an erection—while also obstructing the alpha receptors responsible for constricting the arteries, preventing blood from leaving the penis and allowing you to sustain an erection for longer.

Before intimacy, TriMix is injected into the corpora cavernosa—the chambers of spongy muscle tissue on either side of the penis that fill with blood to create an erection—using a very fine needle. Once injected, the three medications begin to cause the smooth muscle relaxation, vasodilation, and alpha receptor interruption necessary for a firm, long-lasting erection.

Recognized by the American Urological Society as an effective and viable treatment for ED, TriMix is an effective second line of therapy for patients who see limited success with oral PDE5 inhibitors, and delivers a host of benefits, including:

  • Erections that are triggered within 5 to 20 minutes of injection
  • Longer, fuller erections that can last through climax and up to one hour
  • Easy self-administration
  • Simple storage requirements
  • A high success rate for most men
  • Lower risk of side effects, since the drugs work locally at the injection site as opposed to being circulated through the bloodstream like oral medications

TriMix can also be used to treat Peryonie’s Disease in some men.

Getting Started with TriMix Injections

Your first TriMix injection will be done here at The Hormone Zone, under the supervision of one of our trained and experienced physicians, and will serve as a baseline “test dose” for your ideal treatment. You will be instructed on the proper technique and placement of your injection, which is very simple and easy to learn.

After the injection, you will wait in the comfort and privacy of the exam room for about 10 to 20 minutes, or until you achieve an erection.

The goal of the first TriMix injection is to achieve an erection firm enough for sexual penetration. That is about a 6 on a scale of 0 to 10, with zero being no reaction at all and 10 being the most favorable result possible. This is not necessarily an indication of your future results; the initial dose is kept low to prevent prolonged erections during dosage titration.

Depending on your in-office results, your Hormone Zone physician will then provide you with three different doses of TriMix injections of varying and incremental strengths to take home and experiment with. Over the next few days, you will inject one of your TriMix injections at a time—and never more than once in a 24-hour period, regardless of results—and observe your reaction. Once you think you have determined your optimal dosage strength, you will simply contact our office and let us know. We will then specially compound your medication and supply you with six at-home doses.

Unless you or your doctor notice changes in results, or if you begin to experience adverse side effects, this will be your dosage for all future treatment supplies. At The Hormone Zone, we offer routine monitoring, checkups, and follow-ups to ensure you are continuing to see optimal results.

TriMix Injections at The Hormone Zone

For more than 20 years, The Hormone Zone—led by top-rated sexual wellness experts Drs. Robinson and Bosch—has been offering patients a comprehensive approach to sexual health that encompasses all the aspects of optimal living. Healthy erectile function is just one part of your overall well-being, so treating ED in isolation will never produce the results you deserve. Instead of simply addressing the symptoms of ED, the physicians at The Hormone Zone work with you to identify the root causes of it and deliver tailored treatment plans to correct it.

At The Hormone Zone, we embrace the philosophy that your body works best when it’s working together, when your hormones are balanced and your systems are in sync. That’s why we’ve been diligently perfecting our medical protocols since 2006, providing proven, research-based solutions that can be tailored to your body’s unique needs. If a treatment doesn’t work, we don’t offer it; if a treatment isn’t working for you, we’ll do something different. By finding ways to improve your body’s function and performance at the cellular level, you can live with confidence.


How many injections are in the TriMix Injection Package?

On your first visit, your TriMix Injection Package includes your first in-office “test dose,” and three additional “test doses.” For all future TriMix Injection Packages purchased, you will receive the entire supply of ten injections in your optimal dosage at once.

How long do erections triggered by TriMix last?

TriMix can work more quickly than many other methods of ED treatment, with erections occurring within 5 to 20 minutes of injection. Erections typically peak in function about 30 minutes after injection and can last between 1 and 2 hours. Erections lasting over 4 hours are considered a medical emergency requiring immediate care, which usually consists of administering phenylephrine to reverse the erection.

Am I a good candidate for TriMix injections?

Intracavernous injection medications like TriMix are an effective treatment option for men with ED who have had little to no success with PDE5 inhibitors. TriMix injections are often most appropriate for patients with medical conditions that prevent them from taking oral ED drugs, such as men with certain cardiovascular diseases, who have had prostate surgery, or who cannot take PDE5 inhibitors due to certain beta-blockers or concurrent nitrate therapy.

However, TriMix is not recommended for men with:

  • Penile implants
  • Penile abnormalities
  • Leukemia
  • Conditions that increase the risk for priapism (prolonged erections)
  • Bleeding disorders
  • Sickle cell anemia
  • Known allergies to TriMix ingredients
  • Explicit medical advice to refrain from sexual activity

Be sure to inform your Hormone Zone physician of all medications, over-the-counter drugs, herbal products, and other substances you take. TriMix components can interact with some medications, causing adverse reactions or potentially making them less effective.

How often can I use TriMix?

TriMix is safe to use up to three times per week, with injections at least 24 hours apart.

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